Modules

Residency Program Director

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Dr. Osborne
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Radiopharmacy

Performance Objective        








1. Instruments for Radiation Detection/Measurement and their quality control

Dose calibrator (Constancy, Accuracy, Linearity, Geometry)  

Scintillation Well Counter, gamma well counter  

Survey Meters, Thyroid uptake probe    








2. Laminar Flow Hoods: Proper handling, cleaning and decontaminating   

including documentation for different types of hoods.

Vertical Laminar Flow Hood        

Exhaust Hood for I131        

Chemical Exhaust Hood        








3. Molybdenum - 99 generators




elution instructions          

Radionuclidic purity test (Moly Breakthrough)    

Chemical purity test (Alumina ion presence)    

Radioactivity calibration (Tc99m activity measurement in the eluate)  

yield estimation          








4. Radiopharmaceutical preparation Overview, quality control

Explanation of Technetium chemistry, Technetium oxidation states,   

chemistry of Technetium ligand complexes    

Compounding of specific radiopharmaceuticals (MDP, DTPA, SC, MAA, DISIDA, 

MAG3)            

Solid-phase extraction (MAG3)      

Thin layer Chromatography        

Inspection of particle size with light microscope and hemacytometer grid   








5. Radiation Protection, handling of radioactive material


GM survey meter measurement of external and surface radiation levels   

Perform wipe tests on packages for removal of external and surface contamination

Data recording for each package received     

Compliance with ALARA (Time, Distance, Shielding), Occupational exposure limits

Whole Body Badge and extremity dosimeters, Thyroid Bioassay  








6. In Vitro labeling





White Blood Cells labeling with In-111      

Red Cell Mass and Plasma Volume with Cr-51/I-125 HSA